Abstract | PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS: Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin- eosin and histological analysis according to Chiu criteria. RESULTS: Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION: Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.
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Authors | José Lacerda Brasileiro, Celso Maschaschi Inoye, Ricardo Dutra Aydos, Iandara Schettert Silva, Gustavo Ribeiro Falcão, Guido Marks, Daniel Martins Pereira |
Journal | Acta cirurgica brasileira
(Acta Cir Bras)
Vol. 28
Issue 11
Pg. 767-73
(Nov 2013)
ISSN: 1678-2674 [Electronic] Brazil |
PMID | 24316743
(Publication Type: Journal Article)
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Chemical References |
- Vasodilator Agents
- Alprostadil
- Pentoxifylline
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Topics |
- Alprostadil
(pharmacology)
- Animals
- Disease Models, Animal
- Intestinal Mucosa
(blood supply, pathology)
- Intestine, Small
(blood supply, pathology)
- Ischemia
(drug therapy)
- Male
- Pentoxifylline
(pharmacology)
- Rats
- Rats, Wistar
- Reperfusion Injury
(drug therapy)
- Reproducibility of Results
- Time Factors
- Vasodilator Agents
(pharmacology)
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