HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1.

AbstractPURPOSE:
To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1.
METHODS:
Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria.
RESULTS:
Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations.
CONCLUSION:
Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.
AuthorsJosé Lacerda Brasileiro, Celso Maschaschi Inoye, Ricardo Dutra Aydos, Iandara Schettert Silva, Gustavo Ribeiro Falcão, Guido Marks, Daniel Martins Pereira
JournalActa cirurgica brasileira (Acta Cir Bras) Vol. 28 Issue 11 Pg. 767-73 (Nov 2013) ISSN: 1678-2674 [Electronic] Brazil
PMID24316743 (Publication Type: Journal Article)
Chemical References
  • Vasodilator Agents
  • Alprostadil
  • Pentoxifylline
Topics
  • Alprostadil (pharmacology)
  • Animals
  • Disease Models, Animal
  • Intestinal Mucosa (blood supply, pathology)
  • Intestine, Small (blood supply, pathology)
  • Ischemia (drug therapy)
  • Male
  • Pentoxifylline (pharmacology)
  • Rats
  • Rats, Wistar
  • Reperfusion Injury (drug therapy)
  • Reproducibility of Results
  • Time Factors
  • Vasodilator Agents (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: