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[Sneddon-Wilkinson disease: efficacy of intermittent adalimumab therapy after lost response to infliximab and etanercept].

AbstractBACKGROUND:
Sneddon-Wilkinson disease (SWD) is a rare chronic neutrophilic dermatosis. The first-line treatment is dapsone but resistance to treatment may sometimes pose a challenge.
CASE REPORT:
We report a multidrug-resistant patient who responded dramatically before gradually losing response to infliximab and then etanercept. Complete remission was again obtained with adalimumab.
DISCUSSION:
Our case confirms the previously reported dramatic efficacy of anti-TNF biological agents in recalcitrant SWD but highlights the possibility of subsequent loss of response. Furthermore, it illustrates the efficacy of adalimumab in this indication.
AuthorsM Versini, F Mantoux, K Angeli, T Passeron, J-P Lacour
JournalAnnales de dermatologie et de vénéréologie (Ann Dermatol Venereol) Vol. 140 Issue 12 Pg. 797-800 (Dec 2013) ISSN: 0151-9638 [Print] France
Vernacular TitleMaladie de Sneddon-Wilkinson échappant à l'infliximab et à l'étanercept: efficacité de l'adalimumab.
PMID24315227 (Publication Type: Case Reports, English Abstract, Journal Article)
CopyrightCopyright © 2013 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • Infliximab
  • Adalimumab
  • Etanercept
Topics
  • Adalimumab
  • Aged
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Antibodies, Monoclonal (pharmacology, therapeutic use)
  • Antibodies, Monoclonal, Humanized (pharmacology, therapeutic use)
  • Drug Administration Schedule
  • Drug Resistance
  • Drug Substitution
  • Etanercept
  • Humans
  • Immunoglobulin A (blood)
  • Immunoglobulin G (pharmacology, therapeutic use)
  • Immunosuppressive Agents (pharmacology, therapeutic use)
  • Infliximab
  • Male
  • Monoclonal Gammopathy of Undetermined Significance (complications)
  • Neutrophil Infiltration
  • PUVA Therapy
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Skin Diseases, Vesiculobullous (complications, drug therapy, immunology, pathology)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

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