Reactive angioendotheliomatosis associated with cyroglobulinemia in a marathon runner.

Abstract

We report a case of a 65-year-old marathon runner who presented with painful plaques, which were worse in cold weather and progressed to ulceration. A punch biopsy revealed vascular endothelial hyperplasia and an appearance consistent with reactive angioendotheliomatosis (RAE), a rare, but benign disorder of the skin. Subsequent investigations resulted in the diagnosis of type I cryoglobulinemia; the lesions resolved completely following treatment of the underlying disorder with lenalidomide.

• Authors: Ann Boyapati, Sant Khan, Adrian Mar, Adam Sheridan
• Journal: Dermatology online journal (Dermatol Online J) Vol. 19 Issue 11 Pg. 20404 (Nov 15 2013) ISSN: 1087-2108 [Electronic] United States
• PMID: 24314779 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Thalidomide
• Lenalidomide

Topics

• Aged
• Angiogenesis Inhibitors (therapeutic use)
• Cryoglobulinemia (complications, diagnosis)
• Hemangioendothelioma (complications, drug therapy, pathology)
• Humans
• Lenalidomide
• Male
• Running
• Skin Neoplasms (complications, drug therapy, pathology)
• Thalidomide (analogs & derivatives, therapeutic use)