Epstein-Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor.

Abstract

The p73 protein has structural and functional homology with the tumor suppressor p53, which plays an important role in cell cycle regulation, apoptosis, and DNA repair. The p73 locus encodes both a tumor suppressor (TAp73) and a putative oncogene (ΔNp73). p73 May play a significant role in p53-deficient lymphomas infected with Epstein-Barr virus (EBV). EBV produces an asymptomatic infection in the majority of the global population, but it is associated with several human B-cell malignancies. The EBV-encoded Epstein-Barr virus nuclear antigen 3C (EBNA3C) is thought to disrupt the cell cycle checkpoint by interacting directly with p53 family proteins. Doxorubicin, a commonly used chemotherapeutic agent, induces apoptosis through p53 and p73 signaling such that the lowΔNp73 level promotes the p73-mediated intrinsic pathway of apoptosis. In this report, we investigated the mechanism by which EBV infection counters p73α-induced apoptosis through EBNA3C.

• Authors: Sushil Kumar Sahu, Suchitra Mohanty, Amit Kumar, Chanakya N Kundu, Subhash C Verma, Tathagata Choudhuri
• Journal: Virology (Virology) Vol. 448 Pg. 333-43 (Jan 05 2014) ISSN: 1096-0341 [Electronic] United States
• PMID: 24314664 (Publication Type: Journal Article)
• Copyright: © 2013 Published by Elsevier Inc.

Chemical References

• Antigens, Viral
• DNA-Binding Proteins
• EBNA-3C, epstein-barr virus
• Epstein-Barr Virus Nuclear Antigens
• Nuclear Proteins
• TP73 protein, human
• Tumor Protein p73
• Tumor Suppressor Proteins
• delta Np73 protein, human
• Doxorubicin

Topics

• Antigens, Viral (genetics, metabolism)
• Apoptosis (drug effects)
• B-Lymphocytes (cytology, metabolism, virology)
• Cell Line, Tumor
• DNA-Binding Proteins (genetics, metabolism)
• Doxorubicin (pharmacology)
• Epstein-Barr Virus Infections (drug therapy, metabolism, physiopathology, virology)
• Epstein-Barr Virus Nuclear Antigens
• Herpesvirus 4, Human (drug effects, genetics, metabolism)
• Humans
• Nuclear Proteins (genetics, metabolism)
• Protein Binding
• Tumor Protein p73
• Tumor Suppressor Proteins (genetics, metabolism)