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Comparison of the effects of silver phosphate and selenium nanoparticles on Staphylococcus aureus growth reveals potential for selenium particles to prevent infection.

Abstract
Interactions of silver phosphate nanoparticles (SPNPs) and selenium nanoparticles (SeNPs) with Staphylococcus aureus cultures have been studied at the cellular, molecular and protein level. Significant antibacterial effects of both SPNPs and SeNPs on S. aureus were observed. At a concentration of 300 μM, SPNPs caused 37.5% inhibition of bacterial growth and SeNPs totally inhibited bacterial growth. As these effects might have been performed due to the interactions of nanoparticles with DNA and proteins, the interaction of SPNPs or SeNPs with the amplified zntR gene was studied. The presence of nanoparticles decreased the melting temperatures of the nanoparticle complexes with the zntR gene by 23% for SeNPs and by 12% for SPNPs in comparison with the control value. The concentration of bacterial metallothionein was 87% lower in bacteria after application of SPNPs (6.3 μg mg(-1) protein) but was increased by 29% after addition of SeNPs (63 μg mg(-1) protein) compared with the S. aureus control (49 μg mg(-1) protein). Significant antimicrobial effects of the nanoparticles on bacterial growth and DNA integrity provide a promising approach to reducing the risk of bacterial infections that cannot be controlled by the usual antibiotic treatments.
AuthorsDagmar Chudobova, Kristyna Cihalova, Simona Dostalova, Branislav Ruttkay-Nedecky, Miguel Angel Merlos Rodrigo, Katerina Tmejova, Pavel Kopel, Lukas Nejdl, Jiri Kudr, Jaromir Gumulec, Sona Krizkova, Jindrich Kynicky, Rene Kizek, Vojtech Adam
JournalFEMS microbiology letters (FEMS Microbiol Lett) Vol. 351 Issue 2 Pg. 195-201 (Feb 2014) ISSN: 1574-6968 [Electronic] England
PMID24313683 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Phosphates
  • Silver Compounds
  • Selenium
  • silver phosphate
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Microbial Sensitivity Tests
  • Nanoparticles
  • Phosphates (pharmacology)
  • Selenium (pharmacology)
  • Silver Compounds (pharmacology)
  • Staphylococcal Infections (prevention & control)
  • Staphylococcus aureus (drug effects, growth & development)

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