Abstract | PURPOSE:
Ambrisentan (ABS) is an antihypertensive drug used in the treatment of pulmonary atrial hypertension. The survey of literature for ABS revealed only two spectrophotometric methods for its quantification. The reported methods lack the sensitivity. This study is aimed at developing two sensitive extractive spectrophotometric methods for the determination of ABS in bulk and in tablets. METHODS: RESULTS: In both the methods, the calibration curve was linear from 1-15 µg mL(-1) of drug. Apparent molar absorpitivities were 1.7911 x 10(5), 2.3272 x 10(5) L mol(-1) cm(-1); Sandell's sensitivities were 0.0215, 0.0162 µg cm(-2); LOD were 0.182, 0.175 µg mL(-1); LOQ were 0.551, 0.531 µg mL(-1) for methods MB and SO, respectively. The relative standard deviation and percent recovery ranged from 0.206-1.310% and 99.0-101.5%, respectively. CONCLUSION: The results demonstrate that the proposed methods are sensitive, precise, accurate and inexpensive. These methods can easily be used for the assay of ABS in quality control laboratories.
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Authors | Namasani Santhosh Kumar, Avula Prameela Rani, Telu Visalakshi, Chandra Bala Sekharan |
Journal | Advanced pharmaceutical bulletin
(Adv Pharm Bull)
Vol. 3
Issue 1
Pg. 231-7
( 2013)
ISSN: 2228-5881 [Print] Iran |
PMID | 24312841
(Publication Type: Journal Article)
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