Abstract | BACKGROUND: AIM: To investigate if vWF-Ag is able to predict different fibrosis stages and if it is comparable to other fibrosis scores. METHODS: We analysed 294 patients with chronic hepatitis C who underwent biopsy. We assessed stage of liver fibrosis according to Metavir, measured vWF-Ag and calculated different fibrosis scores (APRI, FCI, FORNS, FI, Fib-4) and compared them by AUCs. We also calculated a new score: vWF-Ag/thrombocytes (VITRO score) for prediction of fibrosis. RESULTS: vWF-Ag levels were increasing with stage of fibrosis: F0: vWF-Ag was median 136.5%, FI 140.6%, FII 157.5%, FIII 171.0%, FIV 252.0%; P < 0.001. vWF-Ag and VITRO score produced AUCs of 0.7 and 0.72 for ≥F2, comparable to the AUCs of APRI, Fib-4, FORNS with 0.75, 0.65 and 0.64 (P > 0.05). For ≥F3 AUCs were 0.79 and 0.86 for vWF-Ag and VITRO score, comparable with AUCs of 0.79, 0.86 and 0.87 for APRI, Fib-4 and FORNS. Cirrhosis shows AUCs of 0.84 and 0.89 for vWF-Ag and VITRO score, APRI, Fib-4 and FORNS showed similar results with AUCs of 0.82, 0.88 and 0.87. CONCLUSIONS: vWF-Ag and VITRO score offer an easy possibility to evaluate the stage of fibrosis to diagnose subclinical cirrhosis in patients with chronic hepatitis C. Both vWF-Ag and VITRO score show equal performance in comparison to other fibrosis scores assessed in our study.
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Authors | A Maieron, P Salzl, M Peck-Radosavljevic, M Trauner, S Hametner, R Schöfl, P Ferenci, M Ferlitsch |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 39
Issue 3
Pg. 331-8
(Feb 2014)
ISSN: 1365-2036 [Electronic] England |
PMID | 24308724
(Publication Type: Journal Article)
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Copyright | © 2013 John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- von Willebrand Factor
|
Topics |
- Adult
- Biomarkers
(metabolism)
- Biopsy
- Female
- Hepatitis C, Chronic
(diagnosis, pathology)
- Humans
- Liver Cirrhosis
(diagnosis, pathology)
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- von Willebrand Factor
(metabolism)
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