Abstract | BACKGROUND: MATERIALS AND METHODS: Each group comprised of 100 subjects. Saliva and blood samples were collected from patients with OSCC, premalignant subjects, and normal healthy subjects. Serum and salivary CYFRA 21-1 levels were measured by enzyme-linked immunosorbent assay. Appropriate statistical tests were employed to assess diagnostic potency of CYFRA 21-1. RESULTS: We found a significant increase in CYFRA 21-1 level in OSCC compared with PML and healthy subjects. Salivary CYFRA 21-1 levels in OSCC was threefold higher when compared to serum levels. PML group showed increased salivary CYFRA 21-1 when compared to control subjects, but it was significantly lower compared with OSCC. Receiver operator characteristic curve analysis showed salivary CYFRA 21-1 to have superior sensitivity in detecting OSCC compared with serum CYFRA 21-1. CONCLUSIONS:
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Authors | K Rajkumar, R Ramya, G Nandhini, P Rajashree, A Ramesh Kumar, S Nirmala Anandan |
Journal | Oral diseases
(Oral Dis)
Vol. 21
Issue 1
Pg. 90-6
(Jan 2015)
ISSN: 1601-0825 [Electronic] Denmark |
PMID | 24304502
(Publication Type: Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Keratin-19
- antigen CYFRA21.1
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, Neoplasm
(analysis, blood)
- Biomarkers, Tumor
(analysis, blood)
- Carcinoma, Squamous Cell
(blood, diagnosis)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Keratin-19
(analysis, blood)
- Male
- Middle Aged
- Mouth Neoplasms
(blood, diagnosis)
- Precancerous Conditions
(blood, diagnosis)
- Saliva
(chemistry)
- Young Adult
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