Efficacy of a pegaspargase-based regimen in the treatment of newly-diagnosed extranodal natural killer/T-cell lymphoma.

Abstract

Extranodal natural killer (NK)/T-cell lymphoma (ENKL) is an aggressive neoplasm with poor prognosis. Currently, there is no consensus on the optimal treatment of this disease. In this study, we report the efficacy of a pegaspargase (PEG-Asp)-based chemotherapy, a DDGP regimen (PEG-Asp, dexamethasone, cisplatin, gemcitabine), for the treatment of newly-diagnosed ENKL. From August 2010 to May 2012, 12 patients with newly-diagnosed stage II - IV ENKL were initially treated with a DDGP regimen in our center. Ten patients (10/12, 83.3%) achieved complete response (CR) and two (2/12, 16.7%) achieved partial response (PR). The objective overall response rate (ORR) was 100%. Three patients (3/12, 25.0%) relapsed, and as a result, two died of disease. Eight patients (8/12, 66.7%) were alive with no evidence of disease (NOD) after a median follow-up of 19 months (range 16 - 31 months). Hematologic toxicity was the most frequent toxicity reported in this study. Grade 3/4 leukopenia and neutropenia were common and both occurred in eight patients (8/12, 66.7%), respectively. Additionally, six patients (6/12, 50.0%) experienced grade 3/4 thrombocytopenia and three (3/12, 25.0%) experienced grade 3/4 anemia. However, no patient died of hematologic toxicity. Our results demonstrate the significant efficacy and safety profile of a DDGP regimen in the treatment of newly-diagnosed ENKL, and indicate the potential of this regimen as a first-line therapy against this disease.

• Authors: L Li, C Zhang, L Zhang, X Li, J J Wu, Z C Sun, X R Fu, X H Wang, Y Chang, R Wang, Y J Qiu, M Z Zhang
• Journal: Neoplasma (Neoplasma) Vol. 61 Issue 2 Pg. 225-32 ( 2014) ISSN: 0028-2685 [Print] Slovakia
• PMID: 24299319 (Publication Type: Journal Article)

Chemical References

• Deoxycytidine
• Polyethylene Glycols
• pegaspargase
• Dexamethasone
• Asparaginase
• Cisplatin
• Gemcitabine

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Asparaginase (administration & dosage, adverse effects)
• Cisplatin (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Dexamethasone (administration & dosage)
• Drug-Related Side Effects and Adverse Reactions (classification, pathology)
• Female
• Humans
• Lymphoma, Extranodal NK-T-Cell (drug therapy, pathology)
• Male
• Middle Aged
• Polyethylene Glycols (administration & dosage, adverse effects)
• Remission Induction
• Gemcitabine