Abstract |
We report the first successful use, to our knowledge, of fumagillin alone in a pediatric patient to cure intestinal microsporidiosis in a liver-kidney transplanted child. Detection of Enterocytozoon bieneusi in stool became negative from the first post-therapeutic control, while digestive symptoms disappeared in 4 days. During a 9-month follow-up, polymerase chain reaction and direct examinations remained negative for microsporidia in her feces. No major undesirable effects were noted during the anti-microsporidial therapy.
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Authors | G Desoubeaux, Z Maakaroun-Vermesse, C Lier, E Bailly, F Morio, F Labarthe, L Bernard, J Chandenier |
Journal | Transplant infectious disease : an official journal of the Transplantation Society
(Transpl Infect Dis)
Vol. 15
Issue 6
Pg. E250-9
(Dec 2013)
ISSN: 1399-3062 [Electronic] Denmark |
PMID | 24298986
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antifungal Agents
- Cyclohexanes
- Fatty Acids, Unsaturated
- Sesquiterpenes
- fumagillin
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Topics |
- Antifungal Agents
(therapeutic use)
- Child
- Child, Preschool
- Cyclohexanes
(therapeutic use)
- Diarrhea
(microbiology)
- Enterocytozoon
(genetics, isolation & purification)
- Fatty Acids, Unsaturated
(therapeutic use)
- Feces
(microbiology)
- Female
- Humans
- Kidney Transplantation
(adverse effects)
- Liver Transplantation
(adverse effects)
- Microsporidiosis
(drug therapy, microbiology)
- Sesquiterpenes
(therapeutic use)
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