Abstract | OBJECTIVE: METHODS: Twenty rats were segregated into four experimental groups. The procedure control group consisted of four rats undergoing a sham operation. The remaining 16 rats were divided into two equal groups. The first group (control group) received a continuous intravenous infusion of physiological serum immediately prior to the procedure. Iloprost was administered by a continuous intravenous infusion into the right jugular vein at an infusion rate of 100 ng/kg/min for 30 minutes prior to reperfusion in the experimental group (study group). Following the infusion treatments, ligation of the left coronary artery was conducted for 30 minutes to induce myocardial ischemia. The rats were euthanized 24 hours after reperfusion and cardiac tissue was harvested from all specimens for analysis. RESULTS: Histological examination revealed three myocardial tissue specimens with grade II damage and five myocardial tissue specimens with grade III reperfusion injury in the control group. However, the study group consisted of two grade III myocardial tissue specimens, five grade II myocardial tissue specimens and one grade I myocardial tissue specimen. Moreover, a statistically significant reduction in myocardial edema was observed in the study group (p=0.022). CONCLUSION:
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Authors | A Caliskan, C Yavuz, O Karahan, S Yazici, O Guclu, S Demirtas, B Mavitas |
Journal | Perfusion
(Perfusion)
Vol. 29
Issue 3
Pg. 260-4
(May 2014)
ISSN: 1477-111X [Electronic] England |
PMID | 24297774
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasodilator Agents
- Iloprost
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Topics |
- Animals
- Edema, Cardiac
(etiology, pathology, prevention & control)
- Iloprost
(pharmacology)
- Male
- Myocardial Reperfusion Injury
(complications, drug therapy, pathology)
- Myocardium
(pathology)
- Rats
- Rats, Sprague-Dawley
- Vasodilator Agents
(pharmacology)
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