First clinical application of octacalcium phosphate collagen composite in human bone defect.

Abstract

We have previously demonstrated that octacalcium phosphate (OCP) collagen composite (OCP/collagen) promotes bone regeneration in a critical-sized bone defect of a rodent or canine model. This study was designed to investigate the bone regeneration of OCP/collagen in human bone defect as a first clinical trial. Two patients who had a radicular cyst or apical periodontitis consented to participate in our clinical study, and OCP/collagen was implanted into the defects after operation. Radiographic examination showed effective bone healing in each bone defect at 3 or 6 months. Likewise, computed tomography value significantly increased after implantation. Postoperative wound healing was uneventful, and neither infection nor allergic reaction against OCP/collagen was observed for the entire period. This study demonstrated that OCP/collagen would be safely used and enhanced bone regeneration in human bone defects. To reinforce the efficacy of OCP/collagen as a bone substitute material, it should be compared with other suitable comparators in the future.

• Authors: Tadashi Kawai, Seishi Echigo, Keiko Matsui, Yuji Tanuma, Tetsu Takahashi, Osamu Suzuki, Shinji Kamakura
• Journal: Tissue engineering. Part A (Tissue Eng Part A) Vol. 20 Issue 7-8 Pg. 1336-41 (Apr 2014) ISSN: 1937-335X [Electronic] United States
• PMID: 24294829 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Phosphates
• octacalcium phosphate
• Collagen

Topics

• Adult
• Bone and Bones (diagnostic imaging, drug effects, pathology, surgery)
• Calcium Phosphates (pharmacology)
• Collagen (pharmacology)
• Female
• Humans
• Male
• Prosthesis Implantation
• Tissue Scaffolds (chemistry)
• Tomography, X-Ray Computed
• Young Adult