[Comparative study of the anti-arrhythmia effect of flecainide acetate and prajmalium bitartrate in patients with tachycardiac ventricular rhythm disorders].

Abstract

In an open randomized therapeutic study, 20 patients known to have frequent ventricular premature beats (VPB) and/or ventricular pairs (VP) were treated with both 2 X 200 mg flecainide (F) and 4 X 20 mg prajmalium-bitartrate (P) for 3 months each. There was a drug-free interval of one week between the two therapy phases. 24-hour long-term ECG-registrations were carried out before the start of the therapy phases as well as 1 week, 1 month, 2 months and 3 months after the initiation of antiarrhythmic therapy. After one week, the group as a whole evidenced a VPB reduction of 94% under F and only 57% under P (p less than or equal to 0.05). The percentage of individual patients in whom there was a statistically significant VPB reduction was also higher under F than under P (65% vs. 40%). In the group as a whole, there was a VP reduction of 99% under F and 88% under P (p less than or equal to 0.05) after one week. Of the 13 individuals with frequent VP (over 16 VP/24 h), a significant reduction was seen in 77% under F and only 38% under P. The difference between the two antiarrhythmic agents registered after one week was also observed in the further course of therapy but could no longer be statistically confirmed for the ventricular pairs. An aggravation of ventricular arrhythmias was observed in 2 patients under F and in 3 under P.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: D Andresen, E R von Leitner, K Wegscheider, A Theiss, H Agena, R Schröder
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 75 Issue 7 Pg. 394-401 (Jul 1986) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: Vergleichende Untersuchung über den antiarrhythmischen Effekt von Flecainidacetat und Prajmaliumbitartrat bei Patienten mit tachykarden ventrikulären Rhythmusstörungen.
• PMID: 2429466 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Ajmaline
• Prajmaline
• Flecainide

Topics

• Adult
• Aged
• Ajmaline (analogs & derivatives)
• Cardiac Complexes, Premature (drug therapy)
• Clinical Trials as Topic
• Electrocardiography
• Female
• Flecainide (adverse effects, therapeutic use)
• Heart Ventricles (drug effects)
• Humans
• Male
• Middle Aged
• Prajmaline (adverse effects, therapeutic use)
• Random Allocation
• Tachycardia (drug therapy)