Synchronous occurrence of nasopharyngeal carcinoma and Hodgkin lymphoma.

Abstract

Latent Epstein-Barr virus infection is associated with several lymphoid and epithelial malignancies. This is the first reported case of a patient presenting with synchronous nasopharyngeal carcinoma and Hodgkin lymphoma associated with Epstein-Barr virus. A 17-year-old previously healthy African-American male presented with anterior mediastinal mass and a nasopharyngeal mass. Histology from biopsy of both lesions revealed evidence of Epstein-Barr virus. The patient successfully completed sequential therapies with chemo radiation with no evidence of active disease. Simultaneous occurrence of the two malignancies is undoubtedly a rare event, and their coexistence raises the question of a common etiologic factor.

• Authors: Janalee Stokken, Ryan M Manz, Aron Flagg, L Kate Gowans, Samantha Anne
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 78 Issue 1 Pg. 154-6 (Jan 2014) ISSN: 1872-8464 [Electronic] Ireland
• PMID: 24290306 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Topics

• Adolescent
• Carcinoma
• Epstein-Barr Virus Infections (pathology, therapy)
• Herpesvirus 4, Human (genetics)
• Hodgkin Disease (pathology, therapy, virology)
• Humans
• Male
• Nasopharyngeal Carcinoma
• Nasopharyngeal Neoplasms (pathology, therapy, virology)
• Neoplasms, Multiple Primary (pathology, surgery, virology)
• Polymerase Chain Reaction
• Positron-Emission Tomography
• Tomography, X-Ray Computed