MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6.

Abstract

Our study demonstrates the downregulation of microRNA-183 (miR-183) in retinoblastoma (RB) tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of miR-183 in the RB cell lines Y79, SO-RB50 and WERI-RB1 suppresses cell viability, migration and invasion. Furthermore, the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) was identified as a new target of miR-183, and restoration of the expression of LRP6 rescues the effects induced by miR-183 in RB cells. These results indicate that miR-183 targets and downregulates LRP6 in the growth, migration and invasion of RB cells.

• Authors: Jianwen Wang, Xiaochun Wang, Zhongji Li, Hongtao Liu, Yan Teng
• Journal: The FEBS journal (FEBS J) Vol. 281 Issue 5 Pg. 1355-1365 (Mar 2014) ISSN: 1742-4658 [Electronic] England
• PMID: 24289859 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
• Copyright: © 2013 FEBS.

Chemical References

• 3' Untranslated Regions
• LRP6 protein, human
• Low Density Lipoprotein Receptor-Related Protein-6
• MIRN183 microRNA, human
• MicroRNAs
• RNA, Messenger
• RNA, Neoplasm

Topics

• 3' Untranslated Regions
• Apoptosis (genetics)
• Base Sequence
• Cell Line, Tumor
• Cell Movement (genetics)
• Cell Proliferation
• Down-Regulation
• Humans
• Low Density Lipoprotein Receptor-Related Protein-6 (genetics, metabolism)
• MicroRNAs (chemistry, genetics, metabolism)
• Neoplasm Invasiveness (genetics)
• Nucleic Acid Conformation
• RNA, Messenger (chemistry, genetics, metabolism)
• RNA, Neoplasm (chemistry, genetics, metabolism)
• Retina (metabolism)
• Retinal Neoplasms (genetics, metabolism, pathology)
• Retinoblastoma (genetics, metabolism, pathology)