Roles of mTOR and p-mTOR in gastrointestinal stromal tumors.

Abstract

OBJECTIVE:

This study aimed to examine the relationship between expression of mammal target of rapamycin (mTOR) and phosphorylation of mTOR (p-mTOR) protein in the PI3K/Akt/mTOR signaling pathways in gastrointestinal stromal tumors and relatiuonships with clinical factors.

METHODS:

Immunohistochemistry was used to detect the expression of the associated proteins mTOR, p-mTOR, and phosphorylation of the tumor suppressor genes PTEN, P27, VEGF, and EGFR in 40 cases of gastrointestinal stromal tumors, with division into a very low and low risk group as well as a moderate and high risk group.

RESULTS:

The positive rate of mTOR and p-mTOR was significantly increased in the moderate and high risk group compared with the very low and low risk group. The difference was statistically significant (P<0.05). When grouped according to size, the positive mTOR expression rate exhibited a statistical difference (P<0.05), which was significantly increased in the group of tumors larger than 5 cm. The difference in the positive mTOR and p-mTOR expression rate exhibit no statistical significance among the PTEN, P27, VEGF, and EGFR expression subgroups (P>0.05).

CONCLUSION:

The different expressions of mTOR and p-mTOR in the signal transduction pathway of gastrointestinal stromal tumor in the different degree-of-risk groups suggested that the mTOR and p-mTOR of the signal transduction pathway serve an important function in the occurrence and development of gastrointestinal stromal tumors.

• Authors: Jun-Chuan Li, Hong-Yu Zhu, Ting-Xuan Chen, Lan-Ying Zou, Xiao-Yan Wang, Hui-Chuan Zhao, Jun Xu
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 10 Pg. 5925-8 ( 2013) ISSN: 2476-762X [Electronic] Thailand
• PMID: 24289602 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• CDKN1B protein, human
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Cyclin-Dependent Kinase Inhibitor p27
• MTOR protein, human
• EGFR protein, human
• ErbB Receptors
• TOR Serine-Threonine Kinases
• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Cyclin-Dependent Kinase Inhibitor p27 (metabolism)
• ErbB Receptors (metabolism)
• Female
• Follow-Up Studies
• Gastrointestinal Stromal Tumors (metabolism, pathology)
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Neoplasm Staging
• PTEN Phosphohydrolase (metabolism)
• Phosphorylation
• Prognosis
• TOR Serine-Threonine Kinases (metabolism)
• Vascular Endothelial Growth Factor A (metabolism)
• Young Adult