Involvement of Arabidopsis histone acetyltransferase HAC family genes in the ethylene signaling pathway.

Abstract

Epigenetic modifications play a fundamental role in regulating chromatin dynamics and gene expression. The level of histone acetylation is controlled by two functionally antagonistic enzymes, namely histone acetyltransferase (HAT) and histone deacetylase (HDAC). CREB-binding protein (CBP)/p300 proteins, a subfamily of highly conserved HATs, are involved in various physiological events including proliferation, differentiation and apoptosis. In this work, we study the poorly known function of their homologous genes, the HAC genes, in Arabidopsis. We found that hac1-involved mutants displayed pleiotropic phenotypes, in particular hypersensitivity to ethylene both in the dark and in the light. We also found that the transcriptional levels of ethylene-responsive genes are significantly higher in the hac1hac5 double mutant than in wild-type plants. Moreover, an ethylene synthesis inhibitor cannot release the triple responses of hac mutants. These results suggest that HACs are involved in the ethylene signaling pathway.

• Authors: Chao Li, Jiang Xu, Jian Li, Qingyun Li, Hongchun Yang
• Journal: Plant & cell physiology (Plant Cell Physiol) Vol. 55 Issue 2 Pg. 426-35 (Feb 2014) ISSN: 1471-9053 [Electronic] Japan
• PMID: 24287137 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acids, Cyclic
• Ethylenes
• Histones
• Plant Growth Regulators
• 1-aminocyclopropane-1-carboxylic acid
• ethylene
• Histone Acetyltransferases

Topics

• Acetylation
• Amino Acids, Cyclic (pharmacology)
• Arabidopsis (drug effects, enzymology, genetics, physiology)
• Ethylenes (metabolism, pharmacology)
• Flowers (drug effects, enzymology, genetics, physiology)
• Gene Expression Profiling
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Plant
• Genes, Reporter
• Histone Acetyltransferases (genetics, metabolism)
• Histones (metabolism)
• Multigene Family
• Mutagenesis, Insertional
• Oligonucleotide Array Sequence Analysis
• Phenotype
• Plant Growth Regulators (metabolism, pharmacology)
• Plant Leaves (drug effects, enzymology, genetics, physiology)
• Promoter Regions, Genetic (genetics)
• Seedlings (drug effects, enzymology, genetics, physiology)
• Signal Transduction