Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: RESULTS: In all malignant tumors and in 9 of 18 benign peripheral nerve sheath tumors, a trimethylamine peak was detected, offering the presence of trimethylamine as a sensitive (100%), but not specific (50%), marker of malignant disease. Trimethylamine concentrations (2.2 ± 2.8 vs 6.6 ± 5.8 institutional units; P < .049) and the trimethylamine fraction (27 ± 42 vs 88 ± 22%; P < .012) were lower in benign than malignant peripheral nerve sheath tumors. A trimethylamine fraction threshold of 50% resulted in 100% sensitivity (95% CI, 58.0%-100%) and 72.2% (95% CI, 59.5%-75%) specificity for distinguishing benign from malignant disease. MR spectroscopy and PET results were concordant in 12 of 16 cases, (2 false-positive results for MR spectroscopy and PET each). CONCLUSIONS:
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Authors | L M Fayad, X Wang, J O Blakeley, D J Durand, M A Jacobs, S Demehri, T K Subhawong, T Soldatos, P B Barker |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 35
Issue 5
Pg. 1035-41
(May 2014)
ISSN: 1936-959X [Electronic] United States |
PMID | 24287094
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 by American Journal of Neuroradiology. |
Chemical References |
- Biomarkers, Tumor
- Methylamines
- trimethylamine
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Topics |
- Adolescent
- Adult
- Aged
- Algorithms
- Biomarkers, Tumor
(analysis)
- Child
- Diagnosis, Computer-Assisted
(methods)
- Female
- Humans
- Male
- Methylamines
(analysis)
- Middle Aged
- Nerve Sheath Neoplasms
(chemistry, diagnosis)
- Proton Magnetic Resonance Spectroscopy
(methods)
- Reproducibility of Results
- Sensitivity and Specificity
- Young Adult
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