HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

1-Oleoyl-2-acetyl-glycerol and phorbol diester stimulate Ca2+ influx through Ca2+ channels in neuroblastoma x glioma hybrid NG108-15 cells.

Abstract
The effect of 1-oleoyl-2-acetyl-glycerol (OAG) and the phorbol diester 12-O-tetradecanoyl-phorbol-acetate (TPA) on the intracellular Ca2+ concentration ([Ca2+]i) in NG108-15 cells was studied using a Ca2+ indicator, quin 2. OAG and TPA induced an increase in [Ca2+]i from 100 +/- 19 to 187 +/- 24 nM and 192 +/- 15 nM, respectively, within 15 min. The increase in [Ca2+]i induced by activators of protein kinase C was dependent on the extracellular Ca2+ concentration [Ca2+]o) and was inhibited by the Ca2+ blockers, verapamil and nifedipine. These results indicate that the OAG- and TPA-induced [Ca2+]i increase is mediated by the influx of extracellular Ca2+ through voltage-sensitive Ca2+ channels.
AuthorsT Osugi, T Imaizumi, A Mizushima, S Uchida, H Yoshida
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 126 Issue 1-2 Pg. 47-51 (Jul 15 1986) ISSN: 0014-2999 [Print] Netherlands
PMID2428631 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diglycerides
  • Glycerides
  • Ion Channels
  • 1-oleoyl-2-acetylglycerol
  • Tetradecanoylphorbol Acetate
  • Calcium
Topics
  • Calcium (metabolism)
  • Diglycerides (pharmacology)
  • Glioma (metabolism)
  • Glycerides (pharmacology)
  • Humans
  • Hybrid Cells
  • Ion Channels (drug effects)
  • Kinetics
  • Nervous System Neoplasms (metabolism)
  • Neuroblastoma (metabolism)
  • Tetradecanoylphorbol Acetate (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: