Expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor α in resected acute colonic diverticulitis.

Abstract

AIM:

Inflammation and fibrosis are present in both colonic diverticulitis and Crohn's disease (CD). The molecular pattern of basic fibroblastic growth factor (bFGF) and syndecan 1 (SD1) expression is altered in stenosing CD, but their expression in resected complicated colonic diverticulitis (ACD) is unknown.

METHOD:

The expression of bFGF, SD1 and tumour necrosis factor α (TNF-α) in 20 patients after resection of ACD was compared with 15 patients having a resection for CD. Analysis was conducted using real-time reverse transcriptase polymerase chain reaction in biopsy samples.

RESULTS:

Lymphocytic and neutrophil inflammation scores were similar in both groups (P = 0.771 and P = 0.562). TNF-α and bFGF expression was significantly higher in ACD than in CD (P < 0.0001 and P = 0.009). SD1 expression was similar in both groups (P = 0.841).

CONCLUSION:

TNF-α and bFGF are significantly overexpressed in ACD with respect to CD, whilst SD1 levels do not differ. The findings confirm that inflammation and its association with altered molecular patterns of mucosal healing may play an important role in the phenotype of the diseases.

• Authors: A Tursi, W Elisei, G M Giorgetti, C D Inchingolo, R Nenna, M Picchio, F Giorgio, E Ierardi, G Brandimarte
• Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (Colorectal Dis) Vol. 16 Issue 3 Pg. O98-103 (Mar 2014) ISSN: 1463-1318 [Electronic] England
• PMID: 24283919 (Publication Type: Comparative Study, Journal Article)
• Copyright: Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.

Chemical References

• RNA, Messenger
• SDC1 protein, human
• Syndecan-1
• Tumor Necrosis Factor-alpha
• Fibroblast Growth Factor 2

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Colon (metabolism, pathology)
• Crohn Disease (genetics, pathology)
• Diverticulitis, Colonic (genetics, pathology)
• Female
• Fibroblast Growth Factor 2 (genetics)
• Humans
• Male
• Middle Aged
• RNA, Messenger (genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Syndecan-1 (genetics)
• Tumor Necrosis Factor-alpha (genetics)
• Young Adult