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Pregnancy outcomes and successful rate of nifedipine therapeutic protocol implementation in a hospital of San Juan.

AbstractPRIMARY OBJECTIVE:
evaluation of Nifedipine protocol success defined as postponement of labor for 48 hours.
SECONDARY OBJECTIVE:
evaluation of the presence of risk factors in patients that develop preterm labor and delivery outcome.
MATERIALS AND METHODS:
Chart review retrospective study with patients admitted to the Hospital of the Metropolitan Area of San Juan in the period of January 1,2009 to December 31, 2010 with diagnosis of preterm labor. A total of 382 patient's records were evaluated for inclusion and exclusion criteria. 48 met all the requirements to be included in the study.
RESULTS:
There were 68.8% patients who successfully completed the 48 hours postponement of labor required to administer corticosteroid therapy for fetal lung maturation. Risk factors for preterm labor commonly observed in the study group were urinary tract infection (60.4%), previous preterm labor (43.8%), multiple gestations (12.5%), and preterm premature rupture of membranes (10.4%).
DISCUSSION:
The use of Nifedipine therapy in patients with preterm labor between 24-34 weeks of gestational age can be effective in the postponement of labor for 48 hours so that the patient can receive corticosteroid fetal lung maturation therapy. The most common risk factor observed in this group of patients with preterm labor was urinary tract infection.
AuthorsLeonardo N Catalano, Michelle Villar Diaz, Miguel Vázquez Guzmán, Ivette Negron, Edgardo Rivera Rosa
JournalBoletín de la Asociación Médica de Puerto Rico (Bol Asoc Med P R) Vol. 105 Issue 3 Pg. 13-6 ( 2013) ISSN: 0004-4849 [Print] Puerto Rico
PMID24282914 (Publication Type: Journal Article)
Chemical References
  • Tocolytic Agents
  • Dexamethasone
  • Nifedipine
Topics
  • Adolescent
  • Adult
  • Dexamethasone (pharmacology, therapeutic use)
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Fetal Membranes, Premature Rupture (epidemiology)
  • Fetal Organ Maturity (drug effects)
  • Gestational Age
  • Hospitals, Urban
  • Humans
  • Lung (drug effects, embryology)
  • Nifedipine (administration & dosage, therapeutic use)
  • Obstetric Labor, Premature (drug therapy, epidemiology)
  • Parity
  • Pregnancy
  • Pregnancy Complications, Infectious (epidemiology)
  • Pregnancy Outcome
  • Puerto Rico (epidemiology)
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Tocolytic Agents (administration & dosage, therapeutic use)
  • Urinary Tract Infections (epidemiology)
  • Young Adult

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