[Effect of hydroxyethyl starch, oxypolygelatin and human albumin on the phagocytic function of the reticuloendothelial system in healthy subjects].

Abstract

RES phagocytic function was determined in healthy volunteers prior to and up to 5 h after application of 10 ml/kg body weight of 6% hydroxyethyl starch (450,000; 0.7), 5.5% oxypolygelatin (30,000), or 5.0% human albumin solution. Phagocytosis (phagocytic index K) was evaluated in vivo by intravascular lipid clearance (Lipofundin clearance test). Immediately after infusion, the phagocytic rate increased by 30% in the hydroxyethyl starch group (n = 10; p less than 0.05), 14% in the oxypolygelatin group (n = 10; ns), and 24% in the albumin group (n = 8; ns). 2 h after infusion phagocytosis was still increased by 35% in the hydroxyethyl starch group (n = 10; p less than 0.05), by 18% in the oxypolygelatin group (n = 10; ns), and 13% in the albumin group (n = 8; ns). 5 h after infusion, K values had returned to normal in the albumin group (n = 4), but were still increased by 40% in the hydroxyethyl starch group (n = 4; ns). No statistically significant differences could be established among the 3 groups. The increase in the phagocytic rate, particularly after application of hydroxyethyl starch, might be explained by a dilution effect.

• Authors: G Lenz, V Hempel, H Junger, H Werle, P Buckenmaier
• Journal: Der Anaesthesist (Anaesthesist) Vol. 35 Issue 7 Pg. 423-8 (Jul 1986) ISSN: 0003-2417 [Print] Germany
• Vernacular Title: Auswirkungen von Hydroxyäthylstärke, Oxypolygelatine und Humanalbumin auf die Phagozytosefunktion des Retikuloendothelialen Systems (RES) gesunder Probanden.
• PMID: 2428269 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antigens
• Hydroxyethyl Starch Derivatives
• Lipids
• Serum Albumin
• von Willebrand Factor
• Gelatin
• Factor VIII
• Starch
• oxypolygelatine

Topics

• Adult
• Antigens (analysis)
• Factor VIII (analysis, immunology, metabolism)
• Gelatin (analogs & derivatives, pharmacology)
• Humans
• Hydroxyethyl Starch Derivatives (pharmacology)
• Lipids (blood)
• Mononuclear Phagocyte System (drug effects)
• Phagocytosis (drug effects)
• Serum Albumin (pharmacology)
• Starch (analogs & derivatives)
• von Willebrand Factor