Thyroxine-induced changes of hepatic glucose-6-phosphatase activity and glycogen, protein, RNA and DNA contents in the rat.

Abstract

Thyroxine (T4) in a dose of 0.1 microgram per g body weight caused in the rat a significant increase in hepatic glucose-6-phosphatase activity, while a reduction of this enzyme activity was observed after 1 microgram of T4 per g. The hepatic glycogen content was found to be depleted and a marked elevation in protein, RNA and DNA contents were observed after both doses of T4.

• Authors: A K Paul
• Journal: Acta physiologica Hungarica (Acta Physiol Hung) Vol. 67 Issue 3 Pg. 339-42 ( 1986) ISSN: 0231-424X [Print] Hungary
• PMID: 2428206 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Liver Glycogen
• Proteins
• RNA
• DNA
• Glucose-6-Phosphatase
• Thyroxine

Topics

• Animals
• Body Weight
• DNA (analysis)
• Glucose-6-Phosphatase (metabolism)
• Liver (analysis, drug effects, enzymology)
• Liver Glycogen (analysis)
• Male
• Proteins (analysis)
• RNA (analysis)
• Rats
• Thyroxine (pharmacology)