Abstract | OBJECTIVES: METHODS: Forty patients undergoing open hepatectomy were enrolled in this prospective, randomized, double-blinded, placebo-controlled trial. Patients were divided into 2 groups: the 0.9% saline continuous infusion group (the control group; n=20) and the ropivacaine continuous infusion group (the Ropi group; n=20). Outcomes measured postoperatively were pain score at rest and on movement, sufentanil consumption, incidence of nausea and vomiting, and sedation score across 48 postoperative hours. Time to bowel recovery, liver function change, mean length of hospitalization, patient satisfaction, and other data after 48 postoperative hours were collected until hospital discharge. RESULTS:
Pain scores at rest were lower for the ropivacaine group and reached significance after 8 and 16 hours (P<0.01). Sufentanil consumption (41.50±21.80 vs. 89.70±35.22 μg; P<0.01) after 48 hours, time to bowel recovery (1.80±0.70 vs. 3.15±1.04 d; P<0.01), incidence of nausea and vomiting (1.75±0.72 vs. 2.40±0.68; P<0.05), and mean length of hospitalization (5.6±2.44 vs. 7.35±2.85 d; P<0.01) were significantly reduced, and the sedation score and liver function change were also comparable between the 2 groups. There was no difference with respect to pain scores on movement, nor with respect to patient satisfaction. CONCLUSIONS:
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Authors | Yu Xin, Yu Hong, Li Zhe Yong |
Journal | The Clinical journal of pain
(Clin J Pain)
Vol. 30
Issue 7
Pg. 571-6
(Jul 2014)
ISSN: 1536-5409 [Electronic] United States |
PMID | 24281275
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amides
- Anesthetics, Intravenous
- Anesthetics, Local
- Ropivacaine
- Sufentanil
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Topics |
- Adult
- Amides
(therapeutic use)
- Anesthetics, Intravenous
(therapeutic use)
- Anesthetics, Local
(therapeutic use)
- Double-Blind Method
- Female
- Hepatectomy
(adverse effects)
- Humans
- Liver Diseases
(surgery)
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Ropivacaine
- Sufentanil
(therapeutic use)
- Time Factors
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