HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Glomerular filtration rates in healthy Asians without kidney disease.

AbstractAIM:
The Chronic Kidney Disease Collaboration - Epidemiology (CKD-EPI) glomerular filtration rates (GFR) estimation equation is believed to estimate GFR more accurately in healthy people but this has not been validated in Asians. We studied the distribution of GFR in a multi-ethnic Asian population without CKD, and compared the performance of measures of GFR estimation, including the CKD-EPI equation, Cockroft-Gault equation, and 24-hour urine creatinine clearances.
MATERIALS AND METHODS:
A total of 103 healthy volunteers without a history of kidney disease, hypertension, or diabetes underwent GFR measurement using 3-sample plasma clearance of (99m) Tc-DTPA. Cockroft-Gault estimated GFR and 24-hour urine creatinine clearances were normalized to body surface area.
RESULTS:
The mean measured GFR was 101 ± 15.8 mL/min per 1.73 m(2) and was lowest in Indians (93 ± 12.3 mL/min per 1.73 m(2); P < 0.001). The CKD-EPI equation appears to be more accurate for healthy participants. Estimated GFR correlated with measured GFR (r = 0.57, P < 0.001), and the mean difference is 3.72 ± 14.43 mL/min per 1.73 m(2) (P < 0.001). However, estimating GFR using self-directed 24-hour urine creatinine clearances is poorer than using the CKD-EPI equation.
CONCLUSIONS:
GFR estimation using self-directed 24-hour urine collection for creatinine clearance is less accurate than using the CKD-EPI equation. A larger study is required to clarify GFR in healthy Asians, and the association of health outcomes of Asian kidney donors with lower GFR thresholds.
AuthorsBoon Wee Teo, Hui Xu, Yun Yin Koh, Jialiang Li, Srinivas Subramanian, Arvind Kumar Sinha, Borys Shuter, Qi Chun Toh, Sunil Sethi, Evan J C Lee
JournalNephrology (Carlton, Vic.) (Nephrology (Carlton)) Vol. 19 Issue 2 Pg. 72-9 (Feb 2014) ISSN: 1440-1797 [Electronic] Australia
PMID24279633 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013 Asian Pacific Society of Nephrology.
Chemical References
  • Creatinine
Topics
  • Adult
  • Asian People
  • Creatinine (urine)
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: