[BRAVO and CRUISE: ranibizumab for the treatment of macular edema secondary to retinal vein occlusion].

Abstract

This article summarizes the results of the BRAVO and CRUISE trials, two randomized multicenter studies in patients with macular edema secondary to branch and central retinal vein occlusion, respectively. Randomization was 1:1:1 to 0.3 mg of ranibizumab, 0.5 mg of ranibizumab or placebo. Monthly injections were administered for 6 months followed by a 6-month observation period in which treatment on an on-demand (PRN) basis was applied with 0.5 mg ranibizumab. Patients in the control group were also eligible for 0.5 mg ranibizumab treatment in the observation period. The results showed a significant anatomical and visual improvement in both treatment groups 7 days after the intravitreal injection. PRN treatment with monthly follow-up maintained the visual improvements achieved after the first 6 months of treatment. Patients in the control group who received PRN treatment after the first 6 months showed an anatomical improvement similar to that in the treatment groups but less visual improvement.

• Authors: M S Figueroa, J M Ruiz Moreno
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 87 Suppl 1 Pg. 46-53 (Dec 2012) ISSN: 1989-7286 [Electronic] Spain
• Vernacular Title: BRAVO y CRUISE: ranibizumab en el tratamiento del edema macular secundario a oclusión de la vena de la retina.
• PMID: 24278989 (Publication Type: Comparative Study, English Abstract, Journal Article, Review)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal, Humanized
• Biomarkers
• Drug Implants
• Dexamethasone
• Triamcinolone Acetonide
• Ranibizumab

Topics

• Angiogenesis Inhibitors (administration & dosage, therapeutic use)
• Antibodies, Monoclonal, Humanized (administration & dosage, therapeutic use)
• Biomarkers
• Clinical Trials, Phase III as Topic (statistics & numerical data)
• Dexamethasone (administration & dosage, therapeutic use)
• Drug Implants
• Follow-Up Studies
• Humans
• Intravitreal Injections
• Laser Coagulation
• Macula Lutea (ultrastructure)
• Macular Edema (drug therapy, etiology)
• Multicenter Studies as Topic (statistics & numerical data)
• Randomized Controlled Trials as Topic (statistics & numerical data)
• Ranibizumab
• Retinal Vein Occlusion (complications)
• Treatment Outcome
• Triamcinolone Acetonide (therapeutic use)
• Visual Acuity