Intranasal corticosteroids topical characteristics: side effects, formulation, and volume.

Guidelines from throughout the world recommend intranasal corticosteroids (INSs) as first-line treatment for most patients with moderate to severe allergic rhinitis. In general, limited comparative studies between different INSs have not indicated that one particular steroid moiety is more effective than another in controlling symptoms of allergic rhinitis. However, there are numerous formulations available with different ingredients that may influence a patient's adherence to treatment.
This article looks at topical features with these agents, specifically, formulations, vehicles (aqueous vs aerosol), and side effects such as epistaxis and nasal septal perforation.
Topical side effects are minimal with INSs with the exception of epistaxis. There are major differences in formulations, volumes, and vehicles between INSs, which could affect adherence.
Physicians need to be aware of the different INS attributes to try to match patients' preferences in order to achieve better adherence and improve outcomes in sufferers of allergic rhinitis.
AuthorsDavid A Petty, Michael S Blaiss
JournalAmerican journal of rhinology & allergy (Am J Rhinol Allergy) 2013 Nov-Dec Vol. 27 Issue 6 Pg. 510-3 ISSN: 1945-8932 [Electronic] United States
PMID24274228 (Publication Type: Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Administration, Intranasal
  • Adrenal Cortex Hormones (administration & dosage, adverse effects)
  • Chemistry, Pharmaceutical
  • Humans
  • Medication Adherence
  • Rhinitis, Allergic
  • Rhinitis, Allergic, Perennial (drug therapy)

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