Oral squamous cell carcinoma in two siblings with Fanconi anemia after allogeneic bone marrow transplantation.

Abstract

Fanconi Anemia patients are a high risk group for solid and hematologic malignancies. The risk seems to be influenced by age, chronic graft versus host disease and immunosuppressive drug regimens. Reports of oral malignant transformation in Fanconi Anemia after hematopoietic stem cell transplantation (HSCT) are increasing probably because of longer survival rates. This is the report of an 18- and her 28-year old sister who developed a post-HSCT oral squamous cell carcinoma. There were significant differences regarding time to malignant transformation, marrow donor characteristics and graft versus host disease evolution and treatment. The report reinforce the need for a routine head and neck screening for cancer in this particular syndrome and suggest that familial history should also be considered in Fanconi anemia patients at risk for oral malignancy after HSCT.

• Authors: Cassius Carvalho Torres-Pereira, Roberta Targa Stramandinoli-Zanicotti, José Miguel Amenábar, Laurindo Moacir Sassi, Paola Andrea Galbiatti Pedruzzi, Cleto M Piazzetta, Carmem Bonfim
• Journal: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry (Spec Care Dentist) 2014 Jul-Aug Vol. 34 Issue 4 Pg. 212-5 ISSN: 1754-4505 [Electronic] United States
• PMID: 24274144 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2014 Special Care Dentistry Association and Wiley Periodicals, Inc.

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation
• Carcinoma, Squamous Cell (complications, diagnosis)
• Fanconi Anemia (complications, therapy)
• Female
• Humans
• Mouth Neoplasms (complications, diagnosis)
• Siblings