Impact of prior rituximab on outcomes of autologous stem-cell transplantation in patients with relapsed or refractory aggressive B-cell lymphoma: a multicentre retrospective Spanish group of lymphoma/autologous bone marrow transplant study.

Abstract

The use of highly effective rituximab-containing therapy for treating diffuse large B-cell lymphoma (DLBCL) makes it more difficult to salvage relapsed or refractory patients. Autologous stem-cell transplantation (ASCT) is the reference treatment for these patients, but the impact of previous exposure to rituximab on the subsequent results of ASCT remains unknown. We analysed 248 patients with relapsed or refractory DLBCL or grade 3B follicular lymphoma pre-treated with rituximab as part of first-line therapy (R+ group) who received ASCT, in comparison with a control group of 127 patients without previous exposure to rituximab (R- group). The complete remission (CR) rates were similar in both groups. Multivariate analysis identified age-adjusted International Prognostic Index at diagnosis, extranodal involvement and disease status at transplant, and the number of previous chemotherapy lines as independent factors with a negative influence on CR rate. Compared with R- patients, those in the R+ group had a significantly better progression-free survival (63% vs. 48% at 5 years) and overall survival (72% vs. 61% at 5 years). This observation was independent of other prognostic factors that affected these outcomes. In conclusion, ASCT is no less effective in patients with relapsed or refractory aggressive B-cell lymphoma pre-treated with first-line rituximab-containing therapy than in rituximab-naive patients.

• Authors: Alba M Redondo, Helena Pomares, María J Vidal, María J Pascual, Belén Quereda, Juan M Sancho, Marta Polo, Javier López, Eulogio Conde, Isidro Jarque, Natalia Alonso, María J Ramírez, Pascual Fernández, María J Sayas, María J Requena, Antonio Salar, José D González, Eva González-Barca, Reyes Arranz, Dolores Caballero, Alejandro Martín
• Journal: British journal of haematology (Br J Haematol) Vol. 164 Issue 5 Pg. 668-74 (Mar 2014) ISSN: 1365-2141 [Electronic] England
• PMID: 24274082 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2013 John Wiley & Sons Ltd.

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Rituximab

Topics

• Adolescent
• Adult
• Aged
• Antibodies, Monoclonal, Murine-Derived (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Marrow Transplantation
• Combined Modality Therapy
• Female
• Graft Survival (drug effects)
• Humans
• Kaplan-Meier Estimate
• Lymphoma, Large B-Cell, Diffuse (drug therapy, therapy)
• Male
• Middle Aged
• Prognosis
• Recurrence
• Remission Induction
• Retrospective Studies
• Rituximab
• Salvage Therapy (methods)
• Treatment Outcome
• Young Adult