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Recurrent H3.3 alterations in childhood tumors.

Abstract
Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.
AuthorsAnders M Lindroth, Christoph Plass
JournalNature genetics (Nat Genet) Vol. 45 Issue 12 Pg. 1413-4 (Dec 2013) ISSN: 1546-1718 [Electronic] United States
PMID24270444 (Publication Type: News, Comment)
Chemical References
  • Histones
Topics
  • Bone Neoplasms (genetics)
  • Chondroblastoma (genetics)
  • Giant Cell Tumor of Bone (genetics)
  • Histones (genetics)
  • Humans

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