Abstract |
Elusive for more than half a century, corticotropin-releasing factor (CRF) was finally isolated and characterized in 1981 from ovine hypothalami and shortly thereafter, from rat brains. Thirty years later, much has been learned about the function and localization of CRF and related family members ( Urocortins 1, 2 and 3) and their 2 receptors, CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2). Here, we report the stepwise development of peptide CRF agonists and antagonists, which led to the CRFR1 agonist Stressin1; the long-acting antagonists Astressin2-B which is specific for CRFR2; and Astressin B, which binds to both CRFR1 and CRFR2.This analog has potential for the treatment of CRF-dependent diseases in the periphery, such as irritable bowel syndrome.
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Authors | Jean E Rivier, Catherine L Rivier |
Journal | Frontiers in neuroendocrinology
(Front Neuroendocrinol)
Vol. 35
Issue 2
Pg. 161-70
(Apr 2014)
ISSN: 1095-6808 [Electronic] United States |
PMID | 24269930
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- CRF receptor type 2
- Peptide Fragments
- Peptides, Cyclic
- Receptors, Corticotropin-Releasing Hormone
- astressin B
- cyclo(31-34)(phenylalanyl(12)-norleucyl(21,28)-glutamyl(31)-lysyl(34))acetyl-corticotropin releasing factor (4-41)
- CRF receptor type 1
- Corticotropin-Releasing Hormone
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Topics |
- Animals
- Corticotropin-Releasing Hormone
(analogs & derivatives, antagonists & inhibitors, pharmacology)
- Humans
- Peptide Fragments
(pharmacology)
- Peptides, Cyclic
(pharmacology)
- Receptors, Corticotropin-Releasing Hormone
(agonists)
- Stress, Physiological
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