Malignant fibrous histiocytoma. Expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies.

Abstract

Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. In 4 cases of MFH studied, the tumor cells were found to react uniformly with antibodies to determinants expressed on monocyte macrophages (T-200, Ia, MoS-1, MoS-39, MoR-17). Both spindle and histiocyte-like tumor cells expressed these markers. In contrast, in 8 non-MFH soft tissue tumors, tumor cell reactivity was not observed. The reactivity of the spindle cells of MFH for determinants of monocyte/macrophages favors their origin from tissue histiocytes (facultative fibroblasts). The results support the view that MFH is a tumor of the mononuclear phagocyte system.

• Authors: J A Strauchen, A Dimitriu-Bona
• Journal: The American journal of pathology (Am J Pathol) Vol. 124 Issue 2 Pg. 303-9 (Aug 1986) ISSN: 0002-9440 [Print] United States
• PMID: 2426951 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antigens, Differentiation
• Antigens, Neoplasm
• Antigens, Surface
• monocyte-macrophage differentiation antigen

Topics

• Antibodies, Monoclonal (immunology)
• Antigens, Differentiation
• Antigens, Neoplasm (analysis, immunology)
• Antigens, Surface (analysis, immunology)
• Histiocytoma, Benign Fibrous (immunology)
• Humans
• In Vitro Techniques
• Soft Tissue Neoplasms (immunology)
• Staining and Labeling