Successful combination chemotherapy (cisplatinum, vinblastine, and bleomycin) against peritoneal dissemination of intracranial germ cell tumor.

Abstract

We found combination chemotherapy with cisplatinum, vinblastine, and bleomycin (PVB therapy) effective in the treatment of a patient with a pineal germ cell tumor with peritoneal dissemination. The metastatic complication may have been attributable to the ventriculoperitoneal shunt tube. After the first course of PVB therapy, the disseminated tumors were decreased in size; no residual tumors were detected after the third course by laparoscopic examination, computed tomographic scanning, or echogram. Our results suggest that combined PVB therapy is effective in the treatment of extraneural metastasis from intracranial germ cell tumors.

• Authors: E Kumura, N Arita, T Hayakawa, Y Ushio, H Nakata, A Murasawa, H Mogami, J Ikezoe, Y Minami
• Journal: Neurosurgery (Neurosurgery) Vol. 18 Issue 6 Pg. 802-4 (Jun 1986) ISSN: 0148-396X [Print] United States
• PMID: 2426626 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bleomycin
• Vinblastine
• Cisplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Brain Neoplasms (drug therapy)
• Cisplatin (administration & dosage)
• Humans
• Neoplasms, Germ Cell and Embryonal (drug therapy)
• Peritoneal Neoplasms (drug therapy, secondary)
• Pinealoma (drug therapy)
• Vinblastine (administration & dosage)