PAS kinase: a nutrient sensing regulator of glucose homeostasis.

Abstract

Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease.

• Authors: Desiree DeMille, Julianne H Grose
• Journal: IUBMB life (IUBMB Life) Vol. 65 Issue 11 Pg. 921-9 (Nov 2013) ISSN: 1521-6551 [Electronic] England
• PMID: 24265199 (Publication Type: Journal Article, Review)
• Copyright: © 2013 International Union of Biochemistry and Molecular Biology.

Chemical References

• PAS domain kinases
• Protein Serine-Threonine Kinases
• Glucose

Topics

• Amino Acid Sequence
• Animals
• Diabetes Mellitus (physiopathology)
• Enzyme Activation
• Gene Expression Regulation
• Glucose (metabolism)
• Homeostasis
• Humans
• Phenotype
• Protein Serine-Threonine Kinases (genetics, physiology)
• Saccharomyces cerevisiae (metabolism)
• Sequence Alignment
• Substrate Specificity