Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol.

Abstract

Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year-old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6 mg/m(2)/day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow-up. Sirolimus appears to be effective in lymphangioma but requires further study.

• Authors: Canan Akyüz, Erman Ataş, Ali Varan
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 61 Issue 5 Pg. 931-2 (May 2014) ISSN: 1545-5017 [Electronic] United States
• PMID: 24265139 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Adrenergic beta-Antagonists
• Antibiotics, Antineoplastic
• Propranolol
• Sirolimus

Topics

• Adrenergic beta-Antagonists (adverse effects)
• Antibiotics, Antineoplastic (therapeutic use)
• Child
• Combined Modality Therapy
• Humans
• Lymphangioma (drug therapy, etiology, surgery)
• Male
• Postoperative Complications
• Propranolol (adverse effects)
• Sirolimus (therapeutic use)
• Tongue Neoplasms (drug therapy, etiology, surgery)
• Treatment Outcome