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Cerebral infarctions after intravenous immunoglobulin therapy for ITP in a child.

AbstractBACKGROUND:
Intravenous immunoglobulin is the favored therapy in childhood immune thrombocytopenic purpura. It is usually well tolerated with manageable side effects, but venous and arterial thrombosis following its administration have been described, mostly in adults.
METHODS:
We describe a 3-year-old girl with immune thrombocytopenic purpura and intracranial hemorrhage who received intravenous immunoglobulin therapy and subsequently developed multifocal cerebral infarctions.
RESULTS:
Product specific as well as other factors may play a role in the development of this complication of intravenous immunoglobulin therapy. This is the only reported case of intravenous immunoglobulin-related thrombosis in a child with immune thrombocytopenic purpura and intracranial hemorrhage.
CONCLUSIONS:
Thrombotic complications are associated with intravenous immunoglobulin administration and this includes cerebral infarcts.
AuthorsAdonis Lorenzana, Samira Armin, Animesh Sharma, Iqbal Allarakhia, Alina Witkowski
JournalPediatric neurology (Pediatr Neurol) Vol. 50 Issue 2 Pg. 188-91 (Feb 2014) ISSN: 1873-5150 [Electronic] United States
PMID24262342 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Immunoglobulins, Intravenous
  • Immunologic Factors
Topics
  • Brain (pathology, physiopathology, radiography)
  • Cerebral Infarction (etiology, pathology)
  • Child, Preschool
  • Diffusion Magnetic Resonance Imaging
  • Evoked Potentials, Visual
  • Female
  • Humans
  • Immunoglobulins, Intravenous (adverse effects, therapeutic use)
  • Immunologic Factors (adverse effects, therapeutic use)
  • Intracranial Hemorrhages (complications, pathology, therapy)
  • Magnetic Resonance Imaging
  • Purpura, Thrombocytopenic, Idiopathic (complications, pathology, therapy)
  • Tomography, X-Ray Computed

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