Effect of 5'-nucleotidase inhibitors on mouse immune system and experimental murine tumors.

Abstract

Nucleoticidin and melanocidins A and B exhibited potent inhibitory activity against 5'-nucleotidases from rat liver membrane and snake venom. Nucleoticidin retarded growth of Sarcoma 180 solid tumor, and melanocidins A and B prolonged the survival period of mice bearing B16 melanoma. These inhibitors enhanced phagocytic activity, interleukin-1 production and superoxide-generating activity of murine peritoneal macrophages. The tumor necrosis factor was also induced by the inhibitors. These results suggested that 5'-nucleotidase inhibitors inhibit tumor growth by modification of the immune system.

• Authors: K Uchino, H Ogawara, T Akiyama, S Watanabe, A Fukuchi
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 39 Issue 5 Pg. 682-7 (May 1986) ISSN: 0021-8820 [Print] England
• PMID: 2426233 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Antibiotics, Antineoplastic
• Glycoproteins
• Interleukin-1
• Polysaccharides
• Tumor Necrosis Factor-alpha
• Superoxides
• Interferons
• nucleoticidin
• melanocidin A
• melanocidin B
• Nucleotidases
• 5'-Nucleotidase

Topics

• 5'-Nucleotidase
• Adjuvants, Immunologic
• Animals
• Antibiotics, Antineoplastic (pharmacology)
• Carcinoma, Squamous Cell (drug therapy)
• Cytotoxicity, Immunologic (drug effects)
• Glycoproteins (biosynthesis)
• Humans
• Interferons (biosynthesis)
• Interleukin-1 (metabolism)
• Macrophages (immunology)
• Melanoma (drug therapy)
• Mice
• Mice, Inbred Strains
• Nucleotidases (antagonists & inhibitors)
• Polysaccharides (pharmacology)
• Sarcoma 180 (drug therapy)
• Superoxides (metabolism)
• Tumor Necrosis Factor-alpha