[Cyclic hydroxamic acids as chemosensitizers in cytostatic therapy].

Abstract

In experimental animals with tumors it was studied antitumor activity of spirocyclic hydroxamic acids which could be classified as targeted agents as their target was enzyme histonedeacetylase, which was involved in the neoplastic process. The results showed that the hydroxamic acids were chemosensitizers for anticancer agents increasing their efficacy and enabling the researchers to reduce significantly the therapeutic dose. Also it was showed that hydroxamic acid, containing nitrogen mustard, was effective in the action on tumors with phenotype and genotype of multidrug resistance.

• Authors: N P Konovalova, I V Vystoron, T E Sashenkova, E N Klimanova, D V Mishchenko, U Iu Allaiarova, S A Goncharova, T A Raevskaia, T N Iakushchenko, A V Cherniak
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 59 Issue 5 Pg. 620-2 ( 2013) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 24260891 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Histone Deacetylase Inhibitors
• Hydroxamic Acids
• Cyclophosphamide
• Methotrexate

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Cyclophosphamide (administration & dosage)
• Drug Resistance, Multiple (drug effects)
• Drug Resistance, Neoplasm (drug effects)
• Histone Deacetylase Inhibitors
• Hydroxamic Acids (pharmacology, therapeutic use)
• Leukemia P388 (drug therapy)
• Methotrexate (administration & dosage)
• Neoplasms, Experimental (drug therapy)