Abstract |
Esophageal cancer is the eighth most common cancer and sixth leading cause of cancer associated death worldwide. Besides environmental risk factors, genetic factors might play an important role in the esophageal cancer carcinogenesis. We conducted a hospital based case-control study to evaluate the genetic susceptibility of functional single nucleotide polymorphisms (SNPs) in the microRNAs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were recruited for this study. The hsa-miR-34b/c rs4938723 T>C, pri-miR-124-1 rs531564 C>G, pre-miR-125a rs12975333 G>T and hsa-miR-423 rs6505162 C>A genotypes were determined using Ligation Detection Reaction (LDR) method. Our results demonstrated that hsa-miR-34b/c rs4938723 CC genotype had a decreased risk of ESCC. The association was evident among patients who never drinking. Hsa-miR-423 rs6505162 C>A might associated with a significantly increased risk of ESCC in patients who smoking. These findings indicated that functional polymorphisms hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A might alter individual susceptibility to ESCC. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations are required to confirm current findings.
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Authors | Jun Yin, Xu Wang, Liang Zheng, Yijun Shi, Liming Wang, Aizhong Shao, Weifeng Tang, Guowen Ding, Chao Liu, Ruiping Liu, Suocheng Chen, Haiyong Gu |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 11
Pg. e80570
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24260422
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- MIRN34 microRNA, human
- MicroRNAs
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Topics |
- Adult
- Aged
- Alleles
- Asian People
(genetics)
- Carcinoma, Squamous Cell
(genetics)
- Case-Control Studies
- China
- Esophageal Neoplasms
(genetics)
- Esophageal Squamous Cell Carcinoma
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- MicroRNAs
(genetics)
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk
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