Abstract | BACKGROUND: METHODS: We performed a prospective interventional trail on patients with traumatic ICH on daily high-dose (325 mg) aspirin therapy. All patients received one pack of apheresis platelets. Blood samples were collected before and 1 hour after platelet transfusion. Platelet function was assessed using Verify Now Platelet Function Assay, and a cutoff of greater than 550 aspirin reaction units was used to define functioning platelets (FP). RESULTS: Twenty-eight patients were enrolled in the study. On presentation, 79% (22 of 28) of the patients had nonfunctioning platelets (NFPs), and transfusion of platelets did not improve platelet function as 81% (18 of 22) still had NFP. Of the 22 patients, 4 converted from NFP to FP after transfusion. There was no difference in the progression of ICH (37.5% vs. 30%, p = 0.7) or neurosurgical intervention (12.5% vs. 15%, p = 0.86) between patients with FP and NFP after platelet transfusion. CONCLUSION: Administration of one pack of apheresis platelet did not improve platelet function. In our study, progression of ICH and the need for neurosurgical intervention were independent of platelet function. Further randomized clinical trials are required to assess both the dose dependence effect and role of platelet transfusion in patients on antiplatelet therapy with traumatic ICH. LEVEL OF EVIDENCE: Therapeutic study, level III.
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Authors | Bellal Joseph, Viraj Pandit, Moutamn Sadoun, Christopher G Larkins, Narong Kulvatunyou, Andrew Tang, Matthew Mino, Randall S Friese, Peter Rhee |
Journal | The journal of trauma and acute care surgery
(J Trauma Acute Care Surg)
Vol. 75
Issue 6
Pg. 990-4
(Dec 2013)
ISSN: 2163-0763 [Electronic] United States |
PMID | 24256671
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Platelet Aggregation Inhibitors
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Topics |
- Aged
- Blood Platelets
(physiology)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Intracranial Hemorrhage, Traumatic
(blood, therapy)
- Male
- Platelet Activation
(drug effects)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Platelet Function Tests
- Platelet Transfusion
- Prospective Studies
- Treatment Outcome
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