[New data on the biological action of normal immunoglobulins].

Abstract

Experiments on 2,520 CBA mice (CBA X X C57BL) F1 nice have shown that the injection of homologous serum immunoglobulins (obtained from intact and blood-stimulated animals), made 2 hours after gamma irradiation from a 60Co source, prevents the development of intestinal dysbacteriosis and endogenous infection. The injection of mouse and human immunoglobulins to nonirradiated mice improved their resistance to experimental infection with Escherichia coli live culture, increased the expression of receptors to the Fc-fragments of IgG in peritoneal macrophages and enhanced the physical working capacity of the animals. The preparations containing normal antitissular antibodies have proved to be particularly effective. In mice, rabbits and dogs the preparations under test have produced no changes in the general state of the animals, no local reactions and no disturbances in the cardiovascular activity.

• Authors: A M Ulanova, A D Chukhrov, G A Shal'nova, N N Klemparskaia, T D Kuz'mina
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 5 Pg. 73-7 (May 1986) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Novye dannye o biologicheskom deĭstvii normal'nykh immunoglobulinov.
• PMID: 2425516 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antibodies
• Immunoglobulins
• Receptors, Fc
• gamma-Globulins

Topics

• Animals
• Antibodies (analysis)
• Antigen-Antibody Reactions (radiation effects)
• Dogs
• Dose-Response Relationship, Immunologic
• Escherichia coli Infections (therapy)
• Gamma Rays
• Humans
• Immunization, Passive
• Immunoglobulins (immunology)
• Lethal Dose 50
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Rabbits
• Receptors, Fc (immunology, radiation effects)
• Time Factors
• gamma-Globulins (immunology)