Longitudinal detection of optic nerve head changes by spectral domain optical coherence tomography in early experimental glaucoma.

Abstract

PURPOSE:

We determined if the detection of spectral-domain optical coherence tomography (SDOCT) optic nerve head (ONH) change precedes the detection of confocal scanning laser tomography (CSLT) ONH surface, SDOCT retinal nerve fiber layer (RNFL), scanning laser perimetry (SLP), and multifocal electroretinography (mfERG) change in eight experimental glaucoma (EG) eyes.

METHODS:

Both eyes from eight monkeys were tested at least three times at baseline, and then every 2 weeks following laser-induced chronic unilateral IOP elevation. Event and trend-based definitions of onset in the control and EG eyes for 11 SDOCT neural and connective tissue, CSLT surface, SDOCT RNFL, SLP, and mfERG parameters were explored. The frequency and timing of onset for each parameter were compared using a logrank test.

RESULTS:

Maximum post-laser IOP was 18 to 42 mm Hg in the EG eyes and 12 to 20 mm Hg in the control eyes. For event- and trend-based analyses, onsets were achieved earliest and most frequently within the ONH neural and connective tissues using SDOCT, and at the ONH surface using CSLT. SDOCT ONH neural and connective tissue parameter change preceded or coincided with CSLT ONH surface change in most EG eyes. The SDOCT and SLP measures of RNFL thickness, and mfERG measures of visual function demonstrated similar onset rates, but occurred later than SDOCT ONH and CSLT surface change, and in fewer eyes.

CONCLUSIONS:

SDOCT ONH change detection commonly precedes or coincides with CSLT ONH surface change detection, and consistently precedes RNFLT, SLP, and mfERG change detection in monkey experimental glaucoma.

• Authors: Lin He, Hongli Yang, Stuart K Gardiner, Galen Williams, Christy Hardin, Nicholas G Strouthidis, Brad Fortune, Claude F Burgoyne
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 55 Issue 1 Pg. 574-86 (Jan 29 2014) ISSN: 1552-5783 [Electronic] United States
• PMID: 24255047 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Disease Models, Animal
• Disease Progression
• Glaucoma (complications, diagnosis)
• Macaca mulatta
• Optic Disk (pathology)
• Optic Nerve Diseases (diagnosis, etiology)
• Time Factors
• Tomography, Optical Coherence (methods)