Abstract |
We have studied the HLA associations of MS patients in Arab patients from two regions. Those patients from the Mediterranean area showed an association of MS with HLA-DR2 (p less than 0.001) and -DQw1 (p less than 0.05), whilst in those from the Gulf there was an association with -DRw53 (p less than 0.02). In the Mediterranean patients -DRw52 was negatively associated with MS (p less than 0.05). In the control populations from the two regions there was a considerable variation in the incidence of HLA antigens. Thus, Gulf Arabs had an increased incidence of -DR1 (p less than 0.05), -DR2 (p less than 0.02), -DR6 (p less than 0.05) and decreased incidence of -DR5 (p less than 0.05), -DRw52 (p less than 0.02) and -DQw3 (p less than 0.01) compared to the Mediterranean control population. These findings are discussed in relation to the aetiology of the disease.
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Authors | A S Al-Din, M Al-Saffar, R Siboo, K Behbehani |
Journal | Tissue antigens
(Tissue Antigens)
Vol. 27
Issue 4
Pg. 196-200
(Apr 1986)
ISSN: 0001-2815 [Print] England |
PMID | 2425452
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Epitopes
- HLA-DQ Antigens
- HLA-DR1 Antigen
- HLA-DR2 Antigen
- HLA-DR6 Antigen
- Histocompatibility Antigens Class II
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Topics |
- Alleles
- Epitopes
(analysis)
- Ethnicity
- HLA-DQ Antigens
- HLA-DR1 Antigen
- HLA-DR2 Antigen
- HLA-DR6 Antigen
- Histocompatibility Antigens Class II
(analysis, genetics, immunology)
- Humans
- Kuwait
- Multiple Sclerosis
(genetics, immunology)
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