Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study.

Abstract

BACKGROUND:

NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in Japanese. A previous study has shown that ND2-237 Leu/Met polymorphism modulates the effects of green tea consumption on risk of hypertension. For men with ND2-237Leu, habitual green tea consumption may reduce the risk of hypertension. Moreover, there is a combined effect of ND2-237 Leu/Met polymorphism and alcohol consumption on risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m2). Several beneficial effects of green tea on the kidney have been reported. The objective of this study was to investigate whether ND2-237 Leu/Met polymorphism modifies the effects of green tea consumption on risk of mildly decreased eGFR in male Japanese health check-up examinees.

RESULTS:

For ND2-237Leu genotypic men, after adjustment for confounding factors, green tea consumption may increase the risk of mildly decreased eGFR (P for trend = 0.016). The adjusted odds ratio (OR) for mildly decreased eGFR was significantly higher in subjects with ND2-237Leu who consume ≥6 cups of green tea per day than those who consume ≤1 cup of green tea per day (adjusted OR = 5.647, 95% confidence interval: 1.528-20.88, P = 0.009). On the other hand, for ND2-237Met genotypic men, green tea consumption does not appear to determine the risk of mildly decreased eGFR.

CONCLUSION:

The present results suggest that ND2-237 Leu/Met polymorphism unexpectedly modifies the effects of green tea consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.

• Authors: Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Hirotaka Ochiai, Takako Shirasawa, Hinako Nanri, Hiromi Hoshino, Yutaka Takashima
• Journal: Journal of negative results in biomedicine (J Negat Results Biomed) Vol. 12 Pg. 17 (Nov 20 2013) ISSN: 1477-5751 [Electronic] England
• PMID: 24252463 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tea
• NADH Dehydrogenase
• NADH dehydrogenase subunit 2, human

Topics

• Asian People (genetics)
• Confidence Intervals
• Cross-Sectional Studies
• Genotype
• Glomerular Filtration Rate
• Humans
• Japan
• Kidney Function Tests
• Male
• Middle Aged
• NADH Dehydrogenase (genetics)
• Odds Ratio
• Physical Examination
• Polymorphism, Single Nucleotide (genetics)
• Tea