The effect of the cardiotonic imazodan (CI-914) on myocardial and peripheral hemodynamics in the anesthetized dog.

Abstract

The purpose of this study was to evaluate the effect of the new cardiotonic, imazodan (CI-914), on myocardial hemodynamics and oxygen consumption, and peripheral blood flow distribution. Organ blood flow was measured by the radiolabeled-microsphere-reference-withdrawal technique and myocardial oxygen consumption calculated from arterial and coronary sinus O2 content and blood flow. At inotropic levels, CI-914 decreases mean arterial pressure with a minimal increase in heart rate. CI-914 decreases coronary vascular resistance and increases supply to demand ratio, indicating an active coronary vasodilation. CI-914 does not alter peripheral blood flow distribution, thus suggesting equivalent organ vasodilation. These data suggest that CI-914 may be useful in the treatment of congestive heart failure because of its positive inotropic, coronary vasodilator, and peripheral vasodilator properties.

• Authors: R P Steffen, C M Eldon, D B Evans
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) 1986 May-Jun Vol. 8 Issue 3 Pg. 520-6 ISSN: 0160-2446 [Print] United States
• PMID: 2425167 (Publication Type: Journal Article)

Chemical References

• Aminopyridines
• Cardiotonic Agents
• Pyridazines
• imazodan
• Amrinone

Topics

• Aminopyridines (pharmacology)
• Amrinone
• Animals
• Cardiotonic Agents (pharmacology)
• Dogs
• Female
• Heart (drug effects)
• Hemodynamics (drug effects)
• Male
• Myocardium (metabolism)
• Oxygen Consumption (drug effects)
• Pyridazines (pharmacology)
• Regional Blood Flow (drug effects)