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Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity.

Abstract
The peptide hormone apelin is translated as a 77-residue preproprotein, truncated to the 55-residue proapelin and, subsequently, to 13-36-residue bioactive isoforms named apelin-13 to -36. Proapelin is hypothesized to be cleaved to apelin-36 and then to the shorter isoforms. However, neither the mechanism of proapelin processing nor the endoproteases involved have been determined. We show direct cleavage of proapelin to apelin-13 by proprotein convertase subtilisin/kexin 3 (PCSK3, or furin) in vitro, with no production of longer isoforms. Conversely, neither PCSK1 nor PCSK7 has appreciable proapelin cleavage activity. Furthermore, we show that both proapelin and PCSK3 transcript expression levels are increased in adipose tissue with obesity and during adipogenesis, suggesting that PCSK3 is responsible for proapelin processing in adipose tissue.
AuthorsKyungsoo Shin, Aditya Pandey, Xiang-Qin Liu, Younes Anini, Jan K Rainey
JournalFEBS open bio (FEBS Open Bio) Vol. 3 Pg. 328-33 ( 2013) ISSN: 2211-5463 [Print] England
PMID24251091 (Publication Type: Journal Article)

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