Abstract | BACKGROUND: METHODS: A meta-analysis based on 506 case-control studies was performed. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. RESULTS: The null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk in cancer (for GSTM1: OR = 1.17; 95%CI = 1.14-1.21; for GSTT1: OR = 1.16; 95%CI = 1.11-1.21, respectively). When the analysis was performed based on their smoking history, the risk associated of GSTM1 null and GSTT1 null genotypes with cancer is further increased (for GSTM1: OR = 2.66; 95%CI = 2.19-3.24; for GSTT1: OR = 2.46; 95%CI = 1.83-3.32, respectively). CONCLUSIONS: These findings indicate that GSTM1 and GSTT1 polymorphisms may play critical roles in the development of cancer, especially in smokers.
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Authors | Jianzheng Fang, Shangqian Wang, Shengli Zhang, Shifeng Su, Zhen Song, Yunfei Deng, Hongqing Cui, Hainan Wang, Yi Zhang, Jian Qian, Jinbao Gu, Bianjiang Liu, Pengchao Li, Rui Zhang, Xinnong Liu, Zengjun Wang |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 11
Pg. e78707
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24250808
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- glutathione S-transferase T1
- Glutathione Transferase
- glutathione S-transferase M1
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Topics |
- Case-Control Studies
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
(genetics)
- Humans
- Neoplasms
(genetics, pathology)
- Polymorphism, Single Nucleotide
- Risk Factors
- Smoking
(adverse effects)
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