Abstract | AIMS:
Pruritus is a common symptom of skin diseases, and is associated with impaired sleep quality and a considerable reduction in the patient's quality of life. Recently, it was reported that there are sex-specific differences in scratching behavior in chronic pruritus patients. Namely, female chronic pruritus patients scratch more and have significantly more scratch lesions than male patients. However, few animal studies have examined sex-related differences in scratching behavior. Thus, the present work investigated sex-related differences in animal pruritus using pruritogens, which are often used to create experimental animal models of itching. MAIN METHODS: KEY FINDINGS: Female mice showed significantly higher scratching counts in SLIGRL-NH2-induced pruritus than male mice. Conversely, there was no obvious sex-related difference in scratching behavior for the other pruritogens examined. SIGNIFICANCE: These results indicate that sex-related differences may exist in the pruritogen-responsive neurons that transmit the itch signal induced by SLIGRL-NH2, but not by histamine or 5-HT.
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Authors | Katsunori Yamaura, Ayana Tomono, Eriko Suwa, Koichi Ueno |
Journal | Life sciences
(Life Sci)
Vol. 94
Issue 1
Pg. 54-7
(Jan 14 2014)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 24239643
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Oligopeptides
- seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide
- Serotonin
- Histamine
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Topics |
- Acute Disease
- Animals
- Behavior, Animal
- Chronic Disease
- Disease Models, Animal
- Female
- Histamine
(pharmacology)
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred ICR
- Oligopeptides
(pharmacology)
- Pruritus
(physiopathology)
- Serotonin
(pharmacology)
- Sex Factors
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