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The effect of 3-deazauridine and dipyridamole on uridine utilization by mice.

Abstract
The inhibition of uridine utilization by 3-deazauridine, an inhibitor of uridine kinase, and by dipyridamole, an inhibitor of the facilitated transport of nucleosides was examined. 3-Deazauridine (500 mg/kg) markedly inhibited (greater than 70%) the formation of uracil nucleotides from uridine in liver, kidney, and L1210 tumor cells. The degree of inhibition is greatly reduced by 6 hr after administration of the drug. Dipyridamole (100 mg/kg) did not significantly reduce salvage of uridine by liver or kidney and produced only small, transient reductions in salvage by L1210 tumors. Dipyridamole pretreatment did not alter the rate of clearance of uridine from the plasma.
AuthorsJ D Moyer, N Malinowski, R L Cysyk
JournalEuropean journal of cancer & clinical oncology (Eur J Cancer Clin Oncol) Vol. 22 Issue 3 Pg. 323-7 (Mar 1986) ISSN: 0277-5379 [Print] England
PMID2423341 (Publication Type: Journal Article)
Chemical References
  • Uracil Nucleotides
  • 3-Deazauridine
  • RNA
  • Dipyridamole
  • Uridine
Topics
  • 3-Deazauridine (pharmacology)
  • Animals
  • Dipyridamole (pharmacology)
  • Kidney (metabolism)
  • Leukemia L1210 (metabolism)
  • Liver (metabolism)
  • Male
  • Mice
  • Mice, Inbred Strains
  • RNA (biosynthesis)
  • Spleen (metabolism)
  • Uracil Nucleotides (biosynthesis)
  • Uridine (analogs & derivatives, metabolism)

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