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Examination of aggression and self-injury in children with autism spectrum disorders and serious behavioral problems.

Abstract
This study identified subtypes of aggression in a sample of 206 children with autism spectrum disorder (ASD) who participated in 2 risperidone trials. The narratives were derived from a parent interview about each child's 2 most pressing problems. Five subtypes of aggression emerged: hot aggression only, cold aggression only, self-injurious behavior (SIB) only, aggression and SIB, and nonaggressive. All groups showed a high rate of positive response to risperidone with no differences across subtypes. These study findings extend understanding of aggression in ASD and may be useful to guide further study on biological mechanisms and individualized treatment in ASD.
AuthorsDevon Carroll, Victoria Hallett, Christopher J McDougle, Michael G Aman, James T McCracken, Elaine Tierney, L Eugene Arnold, Denis G Sukhodolsky, Luc Lecavalier, Benjamin L Handen, Naomi Swiezy, Cynthia Johnson, Karen Bearss, Benedetto Vitiello, Lawrence Scahill
JournalChild and adolescent psychiatric clinics of North America (Child Adolesc Psychiatr Clin N Am) Vol. 23 Issue 1 Pg. 57-72 (Jan 2014) ISSN: 1558-0490 [Electronic] United States
PMID24231167 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Antipsychotic Agents
  • Risperidone
Topics
  • Adolescent
  • Aggression (classification, drug effects, psychology)
  • Analysis of Variance
  • Antipsychotic Agents (therapeutic use)
  • Chi-Square Distribution
  • Child
  • Child Development Disorders, Pervasive (drug therapy, psychology)
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Humans
  • Intelligence Tests
  • Male
  • Outcome Assessment, Health Care (statistics & numerical data)
  • Psychiatric Status Rating Scales
  • Randomized Controlled Trials as Topic
  • Risperidone (therapeutic use)
  • Self-Injurious Behavior (classification, drug therapy, psychology)
  • Severity of Illness Index

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